Types Of Benzodiazepines: Short, Intermediate, Long-Acting

Benzodiazepines, often called “benzos,” are prescription medications doctors use to treat anxiety, panic attacks, sleep problems, seizures, and alcohol withdrawal. While all benzodiazepines work in similar ways in the brain, they differ in how long their effects last in your body. These differences are important to understand because it affects how often you need to take them and how they impact your daily life.

Doctors group benzodiazepines into three main categories based on how long they stay active in your system: short-acting, intermediate-acting, and long-acting. Each type has different uses and benefits depending on what condition is being treated and how quickly you need relief.

Short-Acting Benzodiazepines

Short-acting benzodiazepines work quickly but don’t stay in your body for very long. These medications start taking effect soon after you take them, but their effects wear off relatively fast compared to other types of benzodiazepines. Short-acting benzodiazepines include midazolam (Versed) and triazolam (Halcion).

Short-acting benzodiazepines are often used in medical settings for procedures or when quick, temporary relief is needed. Because they leave your system quickly, they may need to be taken more frequently if used for ongoing conditions.

Read more about short-acting benzodiazepines

Intermediate-Acting Benzodiazepines

Intermediate-acting benzodiazepines also begin to take effect fairly quickly after use. This can make them helpful for relieving panic attacks, seizures, and sleeplessness.

Intermediate-acting benzodiazepines include:

• alprazolam (Xanax)
• lorazepam (Ativan)
• clonazepam (Klonopin)
• clobazam
• nitrazepam
• oxazepam
• temazepam (Restoril)
• flunitrazepam (Rohypnol)

Intermediate-acting benzodiazepines offer a good balance between quick relief and lasting effects. They work fast enough to help during acute anxiety or panic episodes, but they also stay in your system long enough that you don’t need to take them as frequently as short-acting options. This makes them popular choices for managing ongoing anxiety disorders and sleep problems.

Long-Acting Benzodiazepines

Long-acting drugs are slowly absorbed in the body. This means it takes a little longer for effects to occur, but when they do, they generally last longer.

Long-acting benzodiazepines include:

• diazepam (Valium)
• chlordiazepoxide (Lithium)
• clorazepate (Tranxene)
• flurazepam (Dalmane)

Long-acting benzodiazepines are often preferred for treating conditions that need steady, all-day relief, such as generalized anxiety disorder or muscle spasms. Because they stay in your system longer, you typically need fewer doses throughout the day compared to shorter-acting options. Read more about long-acting benzodiazepines.

Written by the Addiction Resource Editorial Staff