What Is A Lethal Dose Of Ativan (Lorazepam)?

Ativan is a prescription medication containing lorazepam, a benzodiazepine used to treat anxiety disorders, panic attacks, and sometimes seizures or insomnia. It works by enhancing the effects of a neurotransmitter called GABA in the brain, producing calming and sedating effects, but it carries risks of dependence and withdrawal if used long-term.

There is no conclusive research on the lethal dose of Ativan. A normal dose of Ativan is between 2 to 6 milligrams (mg). Most doses for the treatment of anxiety disorders are about 2 to 3 mg. If a person takes significantly more than the recommended dose, it’s possible that overdose will occur, but death is unlikely.

Learn more about the fatal doses of commonly abused drugs.

How To Determine The Lethal Dose Of Ativan (Lorazepam)

Ativan, known by the generic name as lorazepam, is a benzodiazepine (benzo) used to treat anxiety disorders. Ativan works for anxiety by increasing the availability of gamma-aminobutyric acid (GABA), a neurotransmitter in the brain. This has a depressive effect on the central nervous system.

Though Ativan is safe when taken in prescribed doses, it may result in overdose when taken in excess. Benzodiazepines can be lethal when mixed with other central nervous system depressants, such as opioids or alcohol.

How Likely Is An Ativan Overdose?

The likelihood of an Ativan overdose depends on several critical factors including individual tolerance levels, dosage amount, frequency of use, and whether it’s combined with other substances. When taken alone as prescribed, Ativan and other benzodiazepines are relatively safe. Pure benzodiazepine overdoses rarely result in fatal outcomes because these medications don’t significantly suppress breathing when used by themselves.

The greatest danger occurs when Ativan is mixed with other central nervous system depressants, particularly alcohol, opioids, or other sedative medications. This combination creates an effect that can lead to severe respiratory depression, where breathing becomes dangerously slow or stops entirely, potentially resulting in coma or death.

Even moderate amounts of Ativan can become life-threatening when combined with these substances, as each depressant compounds the effects of the others. This is why healthcare providers strongly warn against mixing benzodiazepines with alcohol or other sedatives.

Get matched with an affordable mental health counselor

Find a Therapist

Answer a few questions to get started

As a BetterHelp affiliate, we receive commissions if you purchase through the BetterHelp links above.

Ad

Combining Ativan (Lorazepam) With Opioids Can Have Lethal Results

The FDA has warned doctors and their patients not to mix Ativan with opioid pain medications because this combination can be deadly. Many people don’t realize how dangerous it is to take these two types of drugs together. When someone takes Ativan and opioids at the same time, both drugs slow down the brain and body in dangerous ways. This powerful combination makes people extremely drowsy and confused, which means they might not realize they’re in serious trouble. The biggest danger is that both drugs slow down breathing, and together they can make breathing so slow that it stops completely.

Mixing opioids with Ativan can result in life-threatening side effects, including:

• serious sedation that can progress to unconsciousness
• severely decreased breathing (respiratory depression)
• coma from oxygen deprivation to the brain
• death from complete respiratory failure

Even tramadol, a pain medication that doctors often think is safer than other opioids, can be deadly when mixed with Ativan. Doctors now carefully check what other medications their patients are taking before prescribing either drug. Many overdose deaths that seemed to be caused by opioids alone actually happened because the person was also taking a benzodiazepine.

Signs Of Ativan (Lorazepam) Overdose

Recognizing the signs of an Ativan overdose can be the difference between life and death, especially since symptoms can develop and worsen rapidly. An overdose occurs when someone takes more of the medication than their body can safely process, leading to impairment of vital functions.

Seek medical attention if you notice any of the following:

• difficulty breathing or very slow, shallow breathing
• extreme drowsiness or falling asleep at inappropriate times
• seizures or convulsions
• an inability to wake someone up or keep them awake
• loss of consciousness or coma
• slurred speech or difficulty speaking clearly
• severe confusion, disorientation, or unusual agitation
• loss of coordination, stumbling, or inability to control movements

Time is critical when dealing with a suspected Ativan overdose, and calling 911 immediately can save a person’s life. Never assume someone will “sleep it off” if they show signs of overdose, as respiratory depression can worsen quickly and become fatal without emergency medical intervention.

What To Do During An Ativan Overdose

Ativan overdose can occur when too much of the drug is taken at once or when it is combined with alcohol, opioids, or other central nervous system depressants. If someone appears to be overdosing, signs may include extreme sedation, slowed or difficult breathing, severe confusion, and loss of consciousness. Call 911 immediately if any of these symptoms are present and do not leave the person alone while waiting for help to arrive.

Place the person on their side if they are unconscious to prevent choking, and monitor their breathing until emergency responders arrive. Tell paramedics exactly what was taken, how much, and whether any other substances were involved, as it can affect how they treat the overdose. If opioids may also have been taken, administer naloxone if it is available.

Written by the Addiction Resource Editorial Staff