What Is A Lethal Dose Of Wellbutrin (Bupropion)?

Medically Reviewed by Johnelle Smith, M.D. on August 1, 2023

Wellbutrin (bupropion) is an antidepressant medication that is sometimes misused for its stimulant effects. But taking an excessive amount of Wellbutrin can cause seizures, overdose, and potentially death.

What Is The Lethal Dose Of Wellbutrin?

Wellbutrin (bupropion) is an antidepressant medication. Taking a very high dose of Wellbutrin alone or in combination with other drugs can have toxic effects.

The standard dosage of Wellbutrin is 150‒300 milligrams (mg) daily for adults. Taking a higher dose of Wellbutrin than prescribed, or misusing it, can cause negative side effects, including overdose.

Learn more about the lethal doses of commonly abused drugs.

Determining The Lethal Dose Of Wellbutrin

Wellbutrin is a non-addictive drug that is rarely fatal on its own. Survival has been reported following the ingestion of as much as 13.5 grams—or 45 times the maximum daily dose.

Overdose and seizures can occur after taking a higher-than-prescribed dosage of Wellbutrin. One case report described a fatal Wellbutrin overdose after a man ingested 23,000 mg of the medication.

Risk Factors For Wellbutrin Overdose

Wellbutrin overdose is uncommon, but it can occur. This may be a sign of drug abuse, stimulant drug addiction, or suicidal ideation.

Potential risk factors for Wellbutrin overdose include:

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What Are The Signs Of A Wellbutrin Overdose?

Wellbutrin overdose can be identified by a number of physical signs and symptoms. Symptoms may be mild to severe in nature and may require medical attention.

Symptoms of a Wellbutrin overdose might include:

  • seizures
  • dilated pupils
  • agitation
  • hallucinations
  • rapid heartbeat
  • loss of consciousness

In severe cases, overdose can cause cardiac arrest and stopped breathing. If someone has collapsed or stopped breathing after taking Wellbutrin, call 911 right away.

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Medically Reviewed by
Johnelle Smith, M.D. on August 1, 2023
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