Naltrexone, also known as Revia and Vivitrol, is a prescription medication that can reduce cravings for opiates and alcohol, as well as block their euphoric effects.
The short-acting form of naltrexone (Revia, Depade) can have effects that last 24 hours on average, while long-acting naltrexone (Vivitrol) has effects that last about one month.
How long this medication lasts depends on the formulation taken, the dose taken, and other personal and biological factors.
How Long The Effects Of Oral Naltrexone Last
Oral naltrexone (Revia, Depade) comes in pill form. It is typically directed for use once a day, once every other day, or once every three days.
Average duration of effects, by dosage:
- 50 milligrams (mg): 24 hours
- 100 milligrams (mg): 48 hours
- 150 milligrams (mg): up to 72 hours
The standard dosage of naltrexone for adults is 50 mg once a day. Your doctor may prescribe a higher or lower dosage based on personal health needs.
How Long The Effects Of Injection Naltrexone Last
Vivitrol is an extended-release (long-acting) form of naltrexone that is administered intramuscularly once every four weeks, or once a month.
The effects of Vivitrol peak twice after administration: first, about two hours after administration, and then once more about two to three days after administration.
Concentrations of Vivitrol in the body begin to decline about 14 days after administration in most people. This doesn’t necessarily affect its efficacy, however.
Side effects of Vivitrol, such as nausea or reactions at the injection site, will generally go away within the first few days after receiving Vivitrol.
Find the right treatment program today.
Call to be connected with a treatment specialist. 100% Free and Confidential.(844) 616-3400
What Can Affect How Long Naltrexone Lasts?
How long the effects of a medication last can vary from person to person, depending on how fast the body breaks down the substance in a person’s system.
Factors that can influence this include:
- age of the person
- use of other medications
- metabolic rate
- liver and kidney function
Certain health conditions, such as liver disease, may affect the metabolism of naltrexone in the body, which can in turn affect the strength and duration of drug effects.
Call Today To Find Naltrexone Treatment Options
Naltrexone is a prescription medication that is proven to help people maintain their sobriety by reducing cravings for alcohol and opioids.
If you’re looking for naltrexone treatment for yourself or a loved one, call our helpline today to find naltrexone treatment options at an addiction rehab center near you.
Published on July 22, 2021
Addiction Resource aims to provide only the most current, accurate information in regards to addiction and addiction treatment, which means we only reference the most credible sources available.
These include peer-reviewed journals, government entities and academic institutions, and leaders in addiction healthcare and advocacy. Learn more about how we safeguard our content by viewing our editorial policy.
- Substance Abuse and Mental Health Services Administration (SAMHSA) — Naltrexone
- U.S. National Library of Medicine: NCBI Bookshelf — Incorporating Alcohol Pharmacologies Into Medical Practice: Chapter 5 - Extended-Release Injectable Naltrexone
- Vivitrol — Dosing & Administration for VIVITROL (naltrexone for extended-release injectable suspension)