Naltrexone is an opioid antagonist medication that is commonly used to treat alcohol use disorder and opioid use disorder. Mania from naltrexone is not a common side effect.
Naltrexone is also sold under the following names:
- Vivitrol (naltrexone injections)
- Revia (naltrexone tablets)
- Depade (naltrexone tablets)
Mania, or manic episodes, with naltrexone use has been reported in a small number of people with a history of major depression or bipolar disorder.
Naltrexone And Bipolar Disorder
Naltrexone is a medication that can affect the levels of dopamine and serotonin, two neurochemicals, in the brain. However, it’s not believed to commonly induce mania.
Manic episodes are a common feature of bipolar disorder, formerly known as manic depression. This type of disorder commonly co-occurs with substance use disorders.
Mania may occur as a rare but serious side effect of various medications, including some antidepressants, steroids, and stimulants.
Can Naltrexone Treat Bipolar Disorder?
Naltrexone has been studied for its potential use for treating mood disorders like bipolar depression. However, this is not one of its primary uses.
Some research indicates that naltrexone may help stabilize mood in people with bipolar disorder. However, additional research has disputed this.
Bipolar disorder, and symptoms of mania, are primarily treated through the use of other pharmacological and behavioral treatments, such as behavioral therapy.
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Signs Of Mania While Taking Naltrexone
Mania is a symptom of certain mental health disorders and can be a rare side effect of certain prescription and illicit drugs.
Signs of mania might include:
- unusually elevated mood
- sleeping very little or not at all
- talking very fast
- easily distracted
- very high level of energy
- impulsive or reckless behavior
- rapid and intense mood swings
- extreme agitation or irritability
Mania can manifest in a number of different ways. This state of mind is associated with an increased risk for suicide, accidents, and unsafe sexual activity.
Is Mania A Common Side Effect Of Naltrexone?
Mania is not a common side effect of naltrexone. If a person does show signs of mania after taking naltrexone, contact the prescribing physician as soon as possible.
Risk Factors For Mania While Taking Naltrexone
Certain factors may increase the risk of experiencing a manic episode after taking naltrexone for a drug or alcohol use disorder.
Risk factors may include:
- history of mania
- personal or family history of mental illness
- taking a high dose of naltrexone
- history of chronic substance abuse
- drug or alcohol abuse
- periods of high stress
Naltrexone-induced mania is not common. If manic episodes do occur during naltrexone treatment, a doctor may recommend a thorough psychological and physical assessment.
Call Today To Learn More About Naltrexone Treatment
Naltrexone is a safe and effective medication when taken as directed. It can effectively block alcohol and opioid cravings and help individuals maintain sobriety.
Millions of people in the United States struggle with alcohol abuse, prescription drug misuse, and co-occurring disorders. If this describes you or a loved one, you’re not alone.
Call us today for more information about naltrexone and how to find naltrexone treatment options for drug or alcohol addiction at a treatment center near you.
Addiction Resource aims to provide only the most current, accurate information in regards to addiction and addiction treatment, which means we only reference the most credible sources available.
These include peer-reviewed journals, government entities and academic institutions, and leaders in addiction healthcare and advocacy. Learn more about how we safeguard our content by viewing our editorial policy.
- Journal of Clinical Psychopharmacology — Naltrexone in Bipolar Disorder With Depression: A Double-Blind, Placebo-Controlled Study
- Cambridge University — Letter to the Editor: Shopping frenzy induced by naltrexone — a paradoxical effect in bipolar disorder?
- Substance Abuse and Mental Health Services Administration (SAMHSA) — Naltrexone
- U.S. Department of Health and Human Services: Office on Women’s Health — Bipolar disorder
- U.S. National Library of Medicine: PubMed — Drug-induced mania