Mixing Cocaine And Wellbutrin: Effects And Risks

Medically Reviewed by Johnelle Smith, M.D. on July 31, 2023

Cocaine and Wellbutrin can be a dangerous and potentially life-threatening combination. Mixing these substances can result in seizures, cardiovascular complications, and increased toxicity.

Dangers Of Mixing Cocaine And Wellbutrin

Both cocaine and Wellbutrin (bupropion) can have life-threatening and potentially fatal results when abused. Combining these substances only increases these health risks.

Wellbutrin is considered non-habit-forming, but some people do abuse it by crushing it and snorting it to produce a high similar to that of cocaine.

Learn more about the dangers of polydrug abuse.

The Effects Of Mixing Cocaine And Wellbutrin

An experimental clinical trial in 2001 studied the effects of cocaine prior to and during the use of bupropion.

Participants were given repeated cocaine doses at 0, 50, and 100 milligrams (mg) per 70 kilograms (kg), while being pretreated with 150 and 300 mg of bupropion per day.

The study found that, while bupropion enhanced some of the effects of cocaine, it didn’t produce significant changes to the subjective or cardiovascular affects of cocaine.

Risks Of Mixing Cocaine And Wellbutrin

While Wellbutrin has been used to treat patients with cocaine addictions, taking the two substances at the same time can be dangerous.


Ohio Recovery Center


Plymouth, Massachusetts

Enhanced Toxicity Of Both Substances

One case study of a 25-year-old woman investigated the simultaneous use of cocaine and bupropion.

The case study revealed the danger of synergistic (a combined effect greater than just one of the substances) cardiovascular and CNS toxicity from mixing cocaine and bupropion.

This increased toxicity can cause:

  • seizures
  • tachycardia, an abnormal heart rhythm of more than 100 beats per minute
  • agitation
  • hypertension, high blood pressure

Cardiovascular Problems

Bupropion and cocaine can both cause significant cardiovascular complications.

These include:

  • increased blood pressure
  • clamped blood vessels
  • decreased oxygen flow in the blood

All of these cardiovascular issues can lead to serious effects including cardiac arrest, stroke, tissue damage, and death.

Increased Chance Of Seizures

If a person overdoses on one or both of these substances, seizures can occur. Cocaine reduces the body’s seizure threshold, and when used with Wellbutrin, the threshold continues to shrink.

In a case report published by the U.S. National Library of Medicine, researchers investigated the importance of bupropion relative to other drugs, including cocaine.

The study found that 17 out of 279 seizures involving bupropion were drug-related. In six of these cases, after cocaine intoxication seizures, bupropion was the third leading cause of drug-related seizures.

All of the people involved in this case were taking the recommended dose of bupropion. This indicates that there is no safe level of cocaine and bupropion that can mix.

Get Treatment For Drug Addiction Today

If you or a loved one are facing drug or alcohol addiction, you can find treatment today. Call us to learn more about taking your first step toward sobriety by getting professional help.

This page does not provide medical advice. See more

Addiction Resource aims to provide only the most current, accurate information in regards to addiction and addiction treatment, which means we only reference the most credible sources available.

These include peer-reviewed journals, government entities and academic institutions, and leaders in addiction healthcare and advocacy. Learn more about how we safeguard our content by viewing our editorial policy.

  • Was this Helpful?
  • YesNo
Medically Reviewed by
Johnelle Smith, M.D. on July 31, 2023


Canton, Massachusetts

Bedrock Recovery Center


Levels of Care:

Payment Options: Insurance Accepted, Self Pay

View Center Profile


Plymouth, Massachusetts

Ohio Recovery Center


Levels of Care:

Payment Options: Insurance Accepted, Self Pay

View Center Profile

Spring Hill Recovery Center

Ashby, Massachusetts


Addiction Resource Logo