Mixing cocaine and Zoloft, known by its generic name as sertraline, can result in serious, life-threatening complications.
Zoloft is an antidepressant, and mixing any antidepressant with cocaine is never a safe combination.
Cocaine causes a “rush” of serotonin. Zoloft is a selective serotonin reuptake inhibitor (SSRI), and as the name suggests, this means they prevent the reuptake of serotonin in the brain.
Mixing these causes a massive flux of serotonin. Creating dangerous levels of serotonin can have major negative impacts on the body and brain.
Learn more about what happens when you combine multiple drugs
What Are The Risks Of Mixing Cocaine And Zoloft?
Some medical professionals have used Zoloft to treat cocaine addiction, but this does not mean that the two should be taken together.
Mixing cocaine and Zoloft at the same time can be dangerous if enough of the substances are ingested.
Leads To Serotonin Syndrome
The biggest concern with mixing cocaine and Zoloft is serotonin syndrome. This is a condition characterized by high levels of serotonin in the brain.
An overload on serotonin can lead to mild symptoms, including:
- excessive sweating
- low fever
- anxiety
- restlessness
- tremors
- increased heartbeat
- shaking and shivering
- diarrhea
- abnormal skin color
More serious side effects that can lead to death include:
- seizures
- coma
- delirium
Fatal serotonin syndrome is unlikely, but it is possible. If it’s treated early enough, the life-threatening symptoms of the syndrome can be reserved.
But according to the U.S. National Library of Medicine, the mortality of severe serotonin syndrome ranges from 2% to 12%, and there were 93 deaths in 2002.
Why Might Someone Mix Cocaine And Zoloft?
This is not necessarily a common drug combination for those looking for a stronger high. People often mix cocaine and Zoloft because they’re treating depression.
Many people who use cocaine are also battling depression. As a stimulant, cocaine activates the reward center of the brain.
When the drug is removed, this can create a physical and emotional letdown. Repeated use can lead to physical dependence and, in many individuals, depression.
Because Zoloft is an effective antidepressant, many turn to this medication to ease the symptoms of depression and get their body back to normal.
However, mixing these two substances is not safe, even if Zoloft is being used to treat depression.
Finding Treatment For Cocaine And Zoloft Addiction
If you or a loved one are struggling with cocaine and Zoloft, there are safe treatment methods to address both the addiction and co-occurring disorders like depression.
Many addiction treatment programs specifically address these co-occurring disorders because substance abuse walks hand-in-hand with emotional well-being.
Call our helpline to learn about treatment centers like this and recovery programs that might work for you or your loved one.
Addiction Resource aims to provide only the most current, accurate information in regards to addiction and addiction treatment, which means we only reference the most credible sources available.
These include peer-reviewed journals, government entities and academic institutions, and leaders in addiction healthcare and advocacy. Learn more about how we safeguard our content by viewing our editorial policy.
- Drug Policy Alliance—10 Facts About Cocaine
https://drugpolicy.org/sites/default/files/cocainefacts_august_2018_1.pdf - U.S. National Library of Medicine—Recognition and treatment of serotonin syndrome
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2464814/#:~:text=Many%20cases%20of%20the%20syndrome,to%20serotonin%20syndrome%20in%202002. - U.S. National Library of Medicine—Antidepressant drugs appear to enhance cocaine-induced toxicity
https://pubmed.ncbi.nlm.nih.gov/10743914/
