Many prescription drugs that are used to treat depression, anxiety, and other mental health disorders can be habit-forming and result in physical dependence.
Physical dependence on a drug can result in what’s known as discontinuation syndrome, or withdrawal, if a person tries to stop taking a drug too quickly or all at once.
Which Antidepressants Require Detox?
A variety of medications, including tricyclic antidepressants and selective serotonin reuptake inhibitors (SSRIs), can cause physical dependence and withdrawal with chronic use. Taking antidepressants for long periods of time can also lead to an increased tolerance to antidepressants.
Common antidepressants that may require detox include:
- fluoxetine (Prozac) detox
- sertraline (Zoloft) detox
- bupropion (Wellbutrin) detox
- atomoxetine (Strattera) detox
- mirtazapine (Remeron) detox
- amitriptyline (Elavil) detox
- paroxetine (Paxil)
- citalopram (Celexa)
This is not a comprehensive list. If you’ve been taking medication for depression or anxiety for some time, talk to your doctor about whether developing a detox plan is necessary for you.
Who Needs To Detox From Antidepressants?
Detoxification, also known as detox, may be necessary for anyone who’s taken a habit-forming antidepressant medication regularly for at least several weeks.
Taking an SSRI medication or other type of antidepressant can cause physical dependence in a short period of time, which can lead to withdrawal with stopped use.
Signs of physical dependence include:
- needing to increase your dose over time
- feeling anxious or “off” if you miss a dose
- feeling physically sick if you miss a dose
Dependence is not the same as drug addiction, although the two can co-occur. People can be physically dependent on a drug without having a drug use disorder, or addiction.
Signs And Symptoms Of Antidepressant Withdrawal
What withdrawal feels and looks like can vary depending on the type of antidepressant you’re taking, as well as factors such as the dosage and your overall health.
Early signs of antidepressant withdrawal can begin to set in within one to two days after your last dose and may last for anywhere from five days to several weeks.
Symptoms of antidepressant withdrawal can include:
- muscle aches
- impaired balance
- ringing in the ears
- mood swings
- numbness or tingling sensations
Withdrawal symptoms generally last longer and are more likely to be severe for those who have severe drug dependence or suddenly stop taking a very high dose all at once.
How Long Does Antidepressant Withdrawal Last?
On average, withdrawal from SSRI antidepressants lasts about five days. For some, antidepressant withdrawal (including but not limited to SSRIs) can last several weeks.
Factors that can affect how long withdrawal lasts include:
- type of antidepressant
- drug half-life
- dose taken
- frequency of use (e.g. once a day)
- overall health
- use of other drugs
- severity of dependence
Antidepressant Detox And Withdrawal Timeline
Tapering off an antidepressant medication, also known as weaning, is generally the preferred method for detoxification. During this process, withdrawal symptoms can still develop.
First Three Days Of Withdrawal
Quitting an antidepressant all at once could cause a reaction within as little as a few hours, or within the first 48 to 72 hours after last use.
At this time, some physical and psychological symptoms—including changes in mood, and flu-like symptoms—may arise.
First Week Of Withdrawal
Withdrawal symptoms will often peak within the first week of stopping or beginning the weaning (tapering) process. The intensity of symptoms during this time may ebb and flow.
Antidepressant withdrawal typically resolves within one to two weeks of taking your last dose, although some may notice lingering symptoms.
For instance, withdrawal symptoms may last longer for people who:
- are detoxing from multiple drugs
- are detoxing from a drug with a long half-life
- have taken an antidepressant for years
- are weaning off of a high dose
Are There Risks To Antidepressant Detox?
Weaning off an antidepressant or stopping your drug use suddenly after taking it for some time can pose certain risks.
Potential risks of detox include:
- rebound anxiety
The best way to prevent dangers associated with antidepressant withdrawal is to consult a doctor about how to safely get off an antidepressant medication.
Consulting a doctor, or getting in touch with a detox professional, can allow you to create a plan for slowly weaning off the medication. This can help prevent severe withdrawal symptoms.
Antidepressant Detox FAQs
Have questions about antidepressant withdrawal? Find answers to some of the most frequently asked questions here.
❓ How Long Does It Take To Detox From SSRIs?
✔️ How long it takes to fully detox will depend on how high a dose you’ve been taking, and other health-related factors. All in all, this may take anywhere from two to 10 weeks.
❓ What Does SSRI Withdrawal Feel Like?
✔️ SSRI withdrawal is often reported as feeling like a case of the flu. You may feel nauseous, more irritable than usual, develop a fever, chills, as well as a return of anxiety and depression.
❓ Can Stopping Antidepressants Cause Psychosis?
✔️ Discontinuing an antidepressant abruptly can cause psychosis in some people. Signs of this may include seeing or hearing things that aren’t there (hallucinations) or developing severe paranoia.
❓ Can Antidepressant Withdrawal Last Years?
✔️ Some people with a long history of antidepressant use report continuing to feel physical and mental withdrawal symptoms for years after they wean off.
This isn’t true for everyone. For others, withdrawal from antidepressant detox will go away within a couple weeks, or a few months at most.
Find Antidepressant Detox Near You
If you’re looking for antidepressant detox for yourself or a loved one, we may be able to help you find a treatment program that’s best suited to meet your needs.
For more information about antidepressant detox, or to find detox treatment options near you, call our helpline today to connect with one of our knowledgeable staff members.
Addiction Resource aims to provide only the most current, accurate information in regards to addiction and addiction treatment, which means we only reference the most credible sources available.
These include peer-reviewed journals, government entities and academic institutions, and leaders in addiction healthcare and advocacy. Learn more about how we safeguard our content by viewing our editorial policy.
- American Family Physician — Antidepressant Discontinuation Syndrome
- American Psychological Association — How hard is it to stop antidepressants?
- Harvard Health Publishing — Going Off Antidepressants
- U.S. National Library of Medicine: MedlinePlus — Sertraline