Zubsolv can produce both high and low blood pressure for those using the medication.
Many factors affect blood pressure while using Zubsolv, such as whether a person develops certain complications that increase or decrease blood pressure.
How Zubsolv Causes High Blood Pressure
One of the side effects of Zubsolv is high blood pressure. In some cases, an increase in blood pressure may be mild. But in others, this can be a greater cause for concern.
If you are worried about increased blood pressure, reach out to your doctor and talk with them about how to better manage your blood pressure and potentially adjust the dose of Zubsolv.
Increased Blood Pressure In The Brain
Zubsolv can dangerously increase the blood pressure in the brain for some people using the medication.
Buprenorphine may also increase cerebrospinal fluid pressure, which surrounds the brain and spinal cord. This can cause severe headaches and loss of vision.
Those who have any of the following conditions should take caution when considering Zubsolv:
- head injury
- brain tumor
- intracranial lesions
- conditions that cause an increase in cerebrospinal fluid pressure
Higher Blood Pressure In The Biliary Tract
Zubsolv may cause an increase in blood pressure in the biliary tract, a life-threatening condition that can cause:
- changes in behavior
- double vision
The biliary tract, or biliary system, consists of the organs and ducts that make and store bile, including the gallbladder and liver.
One clinical trial found that buprenorphine increased the intracholedochal passage pressure after just five minutes, and peaked at seven minutes.
However, the decline of the pressure was also rapid. This indicates that buprenorphine can be used within certain precautions and medical supervision.
Those with existing dysfunction of the biliary tract should take special precautions if using Zubsolv.
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According to the medication guide on Zubsolv from the U.S. Food & Drug Administration (FDA), the most common adverse event not seen in clinical trials was peripheral edema.
Zubsolv can cause peripheral edema, which is the swelling of the hands and lower legs. One of the primary indicators of this condition is increased blood pressure.
Some cases of peripheral edema are harmless (many get this in everyday life, such as after sitting on a long flight).
Others can be more serious, leading to:
- difficulty walking or standing
- decreased blood circulation
- scarring between layers of tissue
- damage to arteries, veins, joints, and muscles
How Zubsolv Causes Low Blood Pressure
For some people using Zubsolv, the medication may cause the opposite reaction in the body and cause low blood pressure. This can be due to multiple factors.
Adrenal Gland Issues
Zubsolv can lead to complications with the adrenal glands, which produce hormones like cortisol and adrenaline.
The adrenal glands help to regulate blood pressure. If Zubsolv is inhibiting the efficiency of the adrenal glands, this may cause serious problems with blood pressure.
One of the symptoms of this condition is a drop in blood pressure caused by Zubsolv. Most people experience this after about one month of using Zubsolv.
Orthostatic hypotension is a condition that can result from using Zubsolv that causes a sudden drop in blood pressure when a person stands or sits up.
Feeling faint or dizzy when getting up is a common side effect of using Zubsolv. If a person taking Zubsolv experiences this drop in blood pressure, they should seek medical attention.
A person using Zubsolv may have a serious allergic reaction to the medication that can cause a drop in blood pressure.
If you lose consciousness or feel your blood pressure decrease significantly, get medical help right away.
Overdose on Zubsolv has been known to cause hypotension, or low blood pressure.
Other signs of Zubsolv overdose include:
- pinpoint pupils
- respiratory depression
If not treated immediately, an overdose on Zubsolv can cause dangerously low blood pressure and, in some cases, death.
Learn More About Zubsolv Treatment
For those struggling with an opioid use disorder, Zubsolv can help to ease the uncomfortable symptoms of withdrawal and provide sustained pain relief.
To learn more about Zubsolv treatment under the care of an addiction treatment program, call our helpline today.
Published on July 7, 2021
Addiction Resource aims to provide only the most current, accurate information in regards to addiction and addiction treatment, which means we only reference the most credible sources available.
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- Mayo Clinic—Edema
- Medical News Today—Zubsolv (buprenorphine/naloxone)
- National Cancer Institute—Definition of biliary tract
- U.S. Food & Drug Administration (FDA)—Label
- U.S. National Library of Medicine: MedlinePlus—Increased intracranial pressure
- U.S. National Library of Medicine: PubMed—The effect of buprenorphine and oxycodone on the intracholedochal passage pressure